I got a comment about this topic which I approved and then could not find. Unfortunately I can't copy and past comments on the moderation page. The guy basically asked why people bother with center fire rifles at all. He mentioned them being impractical to hunt all but the biggest game and talked about the utility and benefit of a .22/.410 over under.
TOR replies: First I think it is important to have a center fire rifle because it is part of a basic 4. Different types of guns are tools with unique capabilities and one can often not duplicate the performance of another. This is the smallest set of weapons that will readily meet a large amount of firearms needs. You can easily have a dozen guns and still find a niche for some sort of new pistol or a whizz bang flat shooting rifle. However if you have a decent .22, a shotgun, a defensive caliber pistol and a center fire rifle you can meet most basic needs. There is a .22 for plinking or small game hunting or potting the unpottable chicken. There is a shotgun for shooting stuff with a shotgun. There is a pistol to keep near the bed in case there is a strange knock at the door late at night or to carry on your person while doing chores.
Back to the subject of center fire rifles. First they are useful for hunting large game. As you mentioned (I searched for that comment for like 20 minutes, wish I could have found it) people will not shoot a deer every day after the world ends. However hunting does put a lot of meat on a lot of tables. Also rifles are good for taking out predators, both two legged and four. In particular center fire rifles will defeat soft (the most common) body armor.
The .22/.410 combo is great for hunting pot sized animals such as rabbits, squirrels and birds at close range. For this role they are hard to beat. However they are not particularly capable of harvesting larger game at any range and are a poor choice for any sort of predator.